Remnant Indices for Estimating Postprandial Lipidemia in Young Women

Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, postprandial hyperlipidemia, no definitive criteria exist, fasting values of lipids lipoproteins had limited efficacy estimating lipidemia. In the present study, we performed fat-ingestion test aimed to propose indices lipoprotein metabolism. Methods: Healthy young Japanese women (n=54, age 21.1 ± 1.0 y) with apolipoprotein E phenotype 3/3 were enrolled. They ingested fat cream (OFTT cream™, Jomo, Japan; 1 g/kg cream, 0.35 fat). Venous blood samples taken before (0 h) at 0.5, 1, 2, 4, 6 h after ingestion. Results: The serum triglyceride (TG) level peaked returned below baseline h. remnant-like particle-TG (RP-TG) increased h, remnant lipoprotein-cholesterol (RLP-C) 4 B48 did not return B100 concentration slightly decreased TG−RP-TG change during but RP-TG/TG rose 2–6 compared value. RP-TG/RLP-C 2–4 Conclusion: After ingestion, while non-remnant TG was stable, increased. content per particle up from size became smaller. indices, RP-TG/RLP-C, may be useful